Urologic oncology survey
Laboratory research
Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells: Lu T, Burdelya LG, Swiatkowski SM, Boiko AD, Howe PH, Stark GR, Gudkov AV, Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

https://doi.org/10.1016/j.urolonc.2004.11.004Get rights and content

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Nuclear factor-kappaB (NFkB) is a transcription factor that is known to activate transcription of genes involved in proliferation, angiogenesis, invasion, and metastasis. Understanding the regulation of NFkB activity in prostate cancer is an important area of research. The authors present data suggesting the regulatory role of transforming growth factor beta2 (TGFb2) in NFkB activity in prostate cancer. They demonstrate that PC-3 cells are resistant to TNFalpha mediated cytotoxicty and by

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