Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 3 , Pages 216-219, May 2006

Prostate adenocarcinoma manifesting as generalized lymphadenopathy

  • Fabiana M. Moura, M.D.

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    • ,
  • Luisimara T. Garcia, M.D.

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    • ,
  • Lúcia P.F. Castro, M.D.

      Affiliations

    • Department of Pathology and Legal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    • ,
  • Teresa C.A. Ferrari, M.D., Ph.D.

      Affiliations

    • Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55-031-32489746; fax: +55-031-32489664.

Received 9 March 2005; received in revised form 28 June 2005; accepted 30 June 2005.

Abstract 

Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. Here, we report the case of a 65-year-old patient with supraclavicular, mediastinal, hilar, and retroperitoneal lymphadenopathy and pulmonary infiltration, which suggested the diagnosis of lymphoma. There were no urinary symptoms, and the serum prostate-specific antigen (PSA) was only mildly increased with a normal free PSA. A biopsy of the supraclavicular lymph node was compatible with adenocarcinoma, whose prostatic origin was shown by immunohistochemical staining with PSA. The origin of the primary tumor was confirmed by directed prostate biopsy. We emphasize that a suspicion of prostate cancer in men with adenocarcinoma of undetermined origin is important for an adequate diagnostic and therapeutic approach.

Keywords:  Prostate adenocarcinoma , Metastatic prostate cancer , Generalized lymphadenopathy , Prostate-specific antigen

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PII: S1078-1439(05)00165-1

doi:10.1016/j.urolonc.2005.06.022

Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 3 , Pages 216-219, May 2006

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