Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 2 , Pages 119-121 , March 2006

Prostate cancer stem cells, telomerase biology, epigenetic modifiers, and molecular systemic therapy for the androgen-independent lethal phenotype

References 

  1. Salm SN , Burger PE , Coetzee S , et al.   TGFβ maintains dormancy of prostatic stem cells in the proximal region of ducts . J Cell Biol . 2005;170:81–90
  2. Burger PE , Xiong X , Coetzee S , et al.   Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue . Proc Natl Acad Sci U S A . 2005;102:7180–7185
  3. Tsujimura A , Koikawa Y , Salm S , et al.   Proximal location of mouse prostate epithelial stem cells (A model of prostatic homeostasis) . J Cell Biol . 2002;157:1257–1265
  4. Xin L , Ide H , Kim Y , et al.   In vivo regeneration of murine prostate from dissociated cell populations of postnatal epithelia and urogenital sinus mesenchyme . Proc Natl Acad Sci U S A . 2003;100(Suppl 1):1189–1903
  5. Bhatia B , Tang S , Yang P , et al.   Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells . Oncogene . 2005;24:3583–3595
  6. Richardson GD , Robson CN , Lang SH , et al.   CD133, a novel marker for human prostatic epithelial stem cells . J Cell Sci . 2004;117:3539–3545
  7. Karhadkar SS , Boya GS , Abdallah N , et al.   Hedgehog signaling in prostate regeneration, neoplasia and metastasis . Nature . 2004;431:707–712
  8. Huss WJ , Gray DR , Werdin ES , et al.   Evidence of pluripotent human prostate stem cells in a human prostate primary xenograft model . Prostate . 2004;60:77–90
  9. Koeneman KS , Pan C , Jin J , et al.   Telomerase activity, telomere length, and DNA ploidy in prostatic intraepithelial neoplasia (PIN) . J Urol . 1998;160:1533–1539
  10. Suenaga M , Soda H , Oka M , et al.   Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells . Int J Cancer . 2002;97:621–625
  11. Iczkowski KA , Huang W , Mazzucchelli R , et al.   Androgen ablation therapy for prostate carcinoma suppresses the immunoreactive telomerase subunit hTERT . Cancer . 2004;100:294–299
  12. Biroccio A , Leonetti C . Telomerase as a new target for the treatment of hormone-refractory prostate cancer . Endocr Relat Cancer . 2004;11:407–421
  13. Asai A , Oshima Y , Yamamoto Y , et al.   A novel telomerase template antagonist (GRN163) as a potential anticancer agent . Cancer Res . 2003;63:3931–3939
  14. Chen Z , Koeneman KS , Corey DR . Consequences of telomerase inhibition and combination treatments for the proliferation of cancer cells . Cancer Res . 2003;63:5917–5925
  15. Hermann MT , Strong MA , Hao LY , et al.   The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability . Cell . 2001;107:67–77
  16. Li S , Crothers J , Haqq CM , et al.   Cellular and gene expression responses involved in the rapid growth inhibition of human cancer cells by RNA interference-mediated depletion of telomerase RNA . J Biol Chem . 2005;280:23709–23717
  17. Meeker AK , DeMarzo AM . Recent advances in telomere biology (implications for human cancer) . Curr Opin Oncol . 2004;16:32–38
  18. Ben-Porath I , Weinberg RA . The signals and pathways activating cellular senescence . Int J Biochem Cell Biol . 2005;37:961–976
  19. Li LC , Carroll PR , Dahiya R . Epigenetic changes in prostate cancer (Implication for diagnosis and treatment) . J Natl Cancer Inst . 2005;97:103–115
  20. Chen CS , Weng SC , Tseng PH , et al.   Histone acetylation- independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes . J Biol Chem . 2005;280:38879–38887
  21. Galsky M , Kelly WK . The development of differentiation agents for the treatment of prostate cancer . Semin Oncol . 2003;30:689–697
  22. Thelen P , Schweyer S , Hemmerlein B , et al.   Expressional changes after histone deacetylase inhibition by valproic acid in LNCaP human prostate cancer cells . Int J Oncol . 2004;24:25–31
  23. Rephaeli A , Blank-Porat D , Tarasenko N , et al.   In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer . Int J Cancer . 2005;116:226–235
  24. Vanoosten RL , Moore JM , Ludwig AT , et al.   Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts . Mol Ther . 2005;11:542–552
  25. Chen L , Meng S , Wang H , et al.   Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824 . Mol Cancer Ther . 2005;4:1311–1319

PII: S1078-1439(05)00301-7

doi: 10.1016/j.urolonc.2005.11.031

Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 2 , Pages 119-121 , March 2006