Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 5 , Pages 403-406, September 2006

Complete response of bony metastatic bladder urothelial cancer to neoadjuvant chemotherapy and cystectomy

  • Fadi N. Joudi, M.D.

      Affiliations

    • Department of Urology, University of Iowa, Iowa City, IA 52242-1089, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-319-356-7221; fax: +1-319-356-3900.
    • ,
  • Laila Dahmoush, M.D.

      Affiliations

    • Department of Pathology, University of Iowa, Iowa City, IA 52242-1089, USA
    • ,
  • David M. Spector, M.D.

      Affiliations

    • Hematology Oncology Consultants, Davenport, IA 52804, USA
    • ,
  • Badrinath R. Konety, M.D.

      Affiliations

    • Department of Urology, University of Iowa, Iowa City, IA 52242-1089, USA

Received 28 June 2005; received in revised form 19 December 2005; accepted 22 December 2005.

Abstract 

We report on a 38-year-old male diagnosed with biopsy-proven bladder urothelial carcinoma metastatic to the bone, who had a complete response to neoadjuvant chemotherapy consisting of carboplatin and gemcitabine. The final pathology of his radical cystoprostatectomy revealed no residual cancer. The patient continues to be without evidence of disease 2 years postoperatively. This case shows that neoadjuvant chemotherapy with nonstandard regimens can yield responses in patients with bone metastases.

Keywords:  Urothelial carcinoma , Metastasis , Chemotherapy , Cystectomy , Survival

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PII: S1078-1439(06)00006-8

doi:10.1016/j.urolonc.2005.12.002

Urologic Oncology: Seminars and Original Investigations
Volume 24, Issue 5 , Pages 403-406, September 2006

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