Urologic Oncology: Seminars and Original Investigations
Volume 25, Issue 2 , Pages 134-140 , March 2007

Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer

  • Charles J. Ryan, M.D.

      Affiliations

    • Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-415-353-9279; fax: +1-415-353-7779.
    • ,
  • Christopher M. Haqq, M.D., Ph.D.

      Affiliations

    • Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • Jeffrey Simko, M.D., Ph.D.

      Affiliations

    • Department of Pathology, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • Daisuke F. Nonaka, Ph.D.

      Affiliations

    • Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • June M. Chan, D.Sci.

      Affiliations

    • Department of Epidemiology and Biostatistics, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • Vivian Weinberg, Ph.D.

      Affiliations

    • Department of Epidemiology and Biostatistics, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • Eric J. Small, M.D.

      Affiliations

    • Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    • ,
  • Ira D. Goldfine, M.D.

      Affiliations

    • Department of Medicine, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA

Received 13 January 2006 ,Revised 29 June 2006 ,Accepted 14 July 2006.

References 

  1. Baserga R. The IGF-I receptor in cancer research. Exp Cell Res. 1999;253:1–6
  2. Hellawell GO, Turner GD, Davies DR, et al. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res. 2002;62:2942–2950
  3. Dhanasekaran SM, Barrette TR, Ghosh D, et al. Delineation of prognostic biomarkers in prostate cancer. Nature. 2001;412:822–826
  4. LaTulippe E, Satagopan J, Smith A, et al. Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res. 2002;62:4499–4506
  5. Lapointe J, Li C, Higgins JP, et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci U S A. 2004;101:811–816
  6. Chott A, Sun Z, Morganstern D, et al. Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor. Am J Pathol. 1999;155:1271–1279
  7. Roth RA, Maddux B, Wong KY, et al. Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors. Endocrinology. 1983;112:1865–1867
  8. Mathieu MC, Clark GM, Allred DC, et al. Insulin receptor expression and clinical outcome in node-negative breast cancer. Proc Assoc Am Physicians. 1997;109:565–571
  9. Pandini G, Vigneri R, Costantino A, et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling. Clin Cancer Res. 1999;5:1935–1944
  10. Hayward SW, Wang Y, Cao M, et al. Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res. 2001;61:8135–8142
  11. Cunha GR, Hayward SW, Wang YZ. Role of stroma in carcinogenesis of the prostate. Differentiation. 2002;70:473–485

☆ NIH K23 CA115775-01 supported C.J.R. National Cancer Institute Grants, P50 CA89520, R01 CA101042-01 supported C.M.H. and J.S. National Cancer Institute Grants P50 CA89520, R01 CA101042-01, and the Prostate Cancer Foundation supported J.M.C. The John Kerner and Jay Gershow Funds of the Mount Zion Health Fund supported I.D.G.

PII: S1078-1439(06)00241-9

doi: 10.1016/j.urolonc.2006.07.019

Urologic Oncology: Seminars and Original Investigations
Volume 25, Issue 2 , Pages 134-140 , March 2007

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