Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 2 , Pages 113-124, March 2008

Molecular markers for predicting prognosis of renal cell carcinoma

Department of Urologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received 8 February 2007; received in revised form 8 March 2007; accepted 15 March 2007. published online 09 November 2007.

Abstract 

Metastatic or recurrent renal cell carcinoma (RCC) carries a poor prognosis and long term survival is rare. However, many small RCCs that are incidentally discovered have an indolent course even without treatment. The variability in clinical outcome is a reflection of the underlying tumor biology. Currently, clinical variables such as tumor stage and histologic grade are widely accepted surrogates for tumor-specific cellular and molecular processes. Ongoing advances in genomic and proteomic technologies have produced an expanding list of molecular markers for predicting prognosis. We review expression array studies evaluating molecular signatures for predicting prognosis in patients with RCC and describe specific prognostic markers that have been validated in at least 50 cases of RCC.

Keywords: Renal cell carcinoma, Molecular markers, Prognosis

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PII: S1078-1439(07)00080-4

doi:10.1016/j.urolonc.2007.03.028

Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 2 , Pages 113-124, March 2008

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