Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 3 , Pages 225-238 , May 2008

Current insights in renal cell cancer pathology

  • Vito Mancini, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-347-1462846; fax: +39-080-5478880.
    • ,
  • Michele Battaglia, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy
    • ,
  • Pasquale Ditonno, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy
    • ,
  • Silvano Palazzo, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy
    • ,
  • Gaetano Lastilla, M.D.

      Affiliations

    • Department of Pathology and Genetics, Pathology Unit, University of Bari, Bari, Italy
    • ,
  • Rodolfo Montironi, M.D.

      Affiliations

    • Pathological Anatomy Section, Polytechnic University–United Hospitals of the Marche Region, Ancona, Italy
    • ,
  • Carlo Bettocchi, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy
    • ,
  • Elisabetta Cavalcanti, Ph.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Nephrology Unit, University of Bari, Bari, Italy
    • ,
  • Elena Ranieri, Ph.D.

      Affiliations

    • Department of Biomedical Science, Clinical Pathology Unit, University of Foggia, Foggia, Italy
    • ,
  • Francesco P. Selvaggi, M.D.

      Affiliations

    • Department of Emergency and Organ Transplantation (D.E.T.O.), Urology and Kidney Transplantation Unit, University of Bari, Bari, Italy

Received 6 March 2007 ,Revised 15 May 2007 ,Accepted 15 May 2007.

References 

  1. International Agency for Research on Cancer (IARC) Cancer Databases, World Health Organization. www-dep.iarc.frAccessed December 15, 2006
  2. Delahunt B, Eble JN. Board of Education of the Royal College of Pathologists of Australasia (Renal cell neoplasia). Pathology. 2002;34:13–20
  3. Nagashima Y, Inayama Y, Kato Y, et al. Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date. Pathol Int. 2004;54:377–386
  4. Mostofi FK, Sesterhenn IA, Sobin LH, et al. Histological typing of kidney tumors. Geneva World Health Organization. 1981;25:1–23
  5. Polascik TJ, Bostwick DG, Cairns P. Molecular genetics and histopathologic features of adult distal nephron tumors. Urology. 2002;60:941–946
  6. Velickovic M, Delahunt B, Grebe SK. Loss of heterozygosity at 3p14.2 in clear cell renal cell carcinoma is an early event and is highly localized to the FHIT gene locus. Cancer Res. 1999;59:1323–1326
  7. Gunawan B, Huber W, Holtrup M, et al. Prognostic impacts of cytogenetic findings in clear cell renal cell carcinoma: Gain of 5q31-qter predicts a distinct clinical phenotype with favorable prognosis. Cancer Res. 2001;61:7731–7738
  8. Kopper L, Timar J. Genomics of renal cell cancer—Does it provide breakthrough?. Pathol Oncol Res. 2006;12:5–11
  9. Yao M, Yoshida M, Kishida T, et al. VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma. J Natl Cancer Inst. 2002;94:1569–1575
  10. Sobin LH, Fleming ID. TNM Classification of Malignant Tumors, fifth edition (Union Internationale Contre le Cancer and the American Joint Committee on Cancer). Cancer. 1997;80:1803–1804
  11. Eble JN, Bonsib SM. Extensively cystic renal neoplasms: Cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. Semin Diagn Pathol. 1998;15:2–20
  12. Delahunt B, Eble JN. History of the development of the classification of renal cell neoplasia. Clin Lab Med. 2005;25:231–246
  13. Kovacs G, Wilkens L, Papp T, et al. Differentiation between papillary and nonpapillary renal cell carcinomas by DNA analysis. J Natl Cancer Inst. 1989;81:527–530
  14. Zbar B, Tory K, Merino M, et al. Hereditary papillary renal cell carcinoma. J Urol. 1994;151:561–566
  15. Renshaw AA, Granter SR, Fletcher JA, et al. Renal cell carcinomas in children and young adults: Increased incidence of papillary architecture and unique subtypes. Am J Surg Pathol. 1999;23:795–802
  16. Delahunt B, Eble JN, McCredie MR, et al. Morphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases. Hum Pathol. 2001;32:590–595
  17. Amin MB, Corless CL, Renshaw AA, et al. Papillary (chromophil) renal cell carcinoma: Histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 62 cases. Am J Surg Pathol. 1997;21:621–635
  18. Tickoo SK, Lee MW, Eble JN, et al. Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. Am J Surg Pathol. 2000;24:1247–1256
  19. Young AN, Amin MB, Moreno CS, et al. Expression profiling of renal epithelial neoplasms: A method for tumor classification and discovery of diagnostic molecular markers. Am J Pathol. 2001;158:1639–1651
  20. van den Berg E, Dijkhuizen T. Classification of renal cell cancer based on (cyto)genetic analysis. Contrib Nephrol. 1999;128:51–61
  21. Brunelli M, Eble JN, Zhang S, et al. Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Pathol. 2005;18:61–69
  22. Bugert P, Gaul C, Weber K, et al. Specific genetic changes of diagnostic importance in chromophobe renal cell carcinomas. Lab Invest. 1997;76:203–208
  23. Nickerson ML, Warren MB, Toro JR, et al. Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome. Cancer Cell. 2002;3:157–164
  24. Castillo M, Petit A, Mellado B, et al. C-kit expression in sarcomatoid renal cell carcinoma: Potential therapy with imatinib. J Urol. 2004;171:2176–2180
  25. Cavazzana AO, Prayer-Galetti T, Tirabosco R, et al. Bellini duct carcinoma (A clinical and in vitro study). Eur Urol. 1996;30:340–344
  26. Schoenberg M, Caims P, Brooks JD, et al. Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes Chromosomes Cancer. 1995;12:76–80
  27. Fuzesi L, Cober M, Mittermayer C. Collecting duct carcinoma: Cytogenetic characterization. Histopathology. 1992;21:155–160
  28. Antonelli A, Portesi E, Cozzoli A, et al. The collecting duct carcinoma of the kidney: A cytogenetical study. Eur Urol. 2003;43:680–685
  29. Khan A, Thomas N, Costello B, et al. Renal medullary carcinoma: Sonographic, computed tomography, magnetic resonance, and angiographic findings. Eur J Radiol. 2000;35:1–7
  30. Argani P, Antonescu CR, Couturier J, et al. PRCCTFE3 renal carcinomas: Morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21). Am J Surg Pathol. 2002;26:1553–1566
  31. Argani P, Antonescu CR, Illei PB, et al. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: A distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol. 2001;159:179–192
  32. Clark J, Lu YJ, Sidhar SK, et al. Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. Oncogene. 1997;15:2233–2239
  33. Eble JN, Epstein JI, Sesterrhenn IA. Pathology and genetics (Tumors of the urinary system and male genital organs). Lyon: IARC Press; 2004;p. 12–78.
  34. Cangiano T, Liao J, Naitoh J, et al. Sarcomatoid renal cell carcinoma: Biologic behavior, prognosis, and response to combined surgical resection and immunotherapy. J Clin Oncol. 1999;17:523
  35. Hou LT, Willis RA. Renal carcino-sarcoma, true and false. J Pathol Bacteriol. 1963;85:139–144
  36. Juhasz J, Sebok J, Galambos J, et al. Renal carcinosarcoma (mixed tumours) of the kidney. Int Urol Nephrol. 1980;12:103–108
  37. Farrow GM, Harrison EG, Utz DC. Sarcomas and sarcomatoid and mixed malignant tumors of the kidney in adults. Cancer. 1968;22:556–563
  38. de Peralta-Venturina M, Moch H, Amin M, et al. Sarcomatoid differentiation in renal cell carcinoma: A study of 101 cases. Am J Surg Pathol. 2001;25:275–284
  39. Mian BM, Bhadkamkar N, Slaton JW, et al. Prognostic factors and survival of patients with sarcomatoid renal cell carcinoma. J Urol. 2002;167:65–70
  40. Dall'Oglio MF, Lieberknecht M, Gouveia V, et al. Sarcomatoid differentiation in renal cell carcinoma: Prognostic implications. Int Braz J Urol. 2005;31:10–16
  41. Jones TD, Eble JN, Wang M, et al. Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation. Cancer. 2005;104:1195–1203
  42. Kuroiwa K, Kinoshita Y, Shiratsuchi H, et al. Renal cell carcinoma with rhabdoid features: An aggressive neoplasm. Histopathology. 2002;41:538–548
  43. Henke RP, Erbersdobler A. Numerical chromosomal aberrations in papillary renal cortical tumors: Relationship with histopathological features. Virchows Arch. 2002;440:604–609
  44. Perez-Ordonez B, Hamed G, Campbell S, et al. Renal Oncocytoma: A clinicopathologic study of 70 cases. Am J Surg Pathol. 1997;21:871–883
  45. Sobin LH, Wittekind C. TNM Classification of Malignant Tumors. 6th ed.. New York: John Wiley and Sons; 2002;
  46. Delahunt B, Kittelson JM, McCredie MR, et al. Prognostic importance of tumor size for localized conventional (clear cell) renal cell carcinoma: Assessment of TNM T1 and T2 tumor categories and comparison with other prognostic parameters. Cancer. 2002;94:658–664
  47. Han KR, Bui MH, Pantuck AJ, et al. TNM T3a renal cell carcinoma: Adrenal gland involvement is not the same as renal fat invasion. J Urol. 2003;169:899–903
  48. Thompson RH, Leibovich BC, Cheville JC, et al. Should direct ipsilateral adrenal invasion from renal cell carcinoma be classified as pT3a?. J Urol. 2005;173:918–921
  49. Thompson RH, Leibovich BC, Cheville JC, et al. Is renal sinus fat invasion the same as perinephric fat invasion for pT3a renal cell carcinoma?. J Urol. 2005;174:1218–1221
  50. Karakiewicz PI, Lewinshtein DJ, Chun FK, et al. Tumor size improves the accuracy of TNM predictions in patients with renal cancer. Eur Urol. 2006;50:521–529
  51. Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982;6:653–663
  52. Ficarra V, Righetti R, Martignoni G, et al. Prognostic value of renal cell carcinoma nuclear grading: Multivariate analysis of 333 cases. Urol Int. 2001;67:130–134
  53. Fiori E, De Cesare A, Galati G, et al. Prognostic significance of primary-tumor extension, stage, and grade of nuclear differentiation in patients with renal cell carcinoma. J Exp Clin Cancer Res. 2002;21:229–232655–63.
  54. Lohse CM, Blute ML, Zincke H, et al. Comparison of standardized and nonstandardized nuclear grade of renal cell carcinoma to predict outcome among 2042 patients. Am J Clin Pathol. 2002;118:877–886
  55. Gudbjartsson T, Hardarson S, Petursdottir V, et al. Histological subtyping and nuclear grading of renal cell carcinoma and their implications for survival: A retrospective nation-wide study of 629 patients. Eur Urol. 2005;48:593–600
  56. Lopez-Beltran A, Scarpelli M, Montironi R, et al. 2004 WHO classification of renal tumors of the adults. Eur Urol. 2006;49:798–805
  57. Leibovitch I, Lev R, Mor Y, et al. Extensive necrosis in renal cell carcinoma specimens: Potential clinical and prognostic implications. Isr Med Assoc J. 2001;3:563–565
  58. Lang H, Lindner V, Letourneux H, et al. Prognostic value of microscopic venous invasion in renal cell carcinoma: Long-term follow-up. Eur Urol. 2004;46:331–335
  59. Giuliani L, Giberti C, Martorana G, et al. Radical extensive surgery for renal cell carcinoma: Long-term results and prognostic factors. J Urol. 1990;143:468–474
  60. Minervini A, Lilas L, Morelli G, et al. Regional lymph node dissection in the treatment of renal cell carcinoma: Is it useful in patients with no suspected adenopathy before or during surgery?. BJU Int. 2001;88:169–172
  61. Sobin LH, Wittekind CH International Union Against Cancer (UICC). TNM classification of malignant tumors. 6th ed.. New York: Wiley-Liss Publications; 2002;
  62. Joslyn SA, Sirintrapun SJ, Konety BR. Impact of lymphadenectomy and nodal burden in renal cell carcinoma: Retrospective analysis of the National Surveillance, Epidemiology, and End Results database. Urology. 2005;65:675–680
  63. Pantuck AJ, Zisman A, Dorey F, et al. Renal cell carcinoma with retroperitoneal lymph nodes: Role of lymph node dissection. J Urol. 2003;169:2076–2083
  64. Pantuck AJ, Zisman A, Dorey F, et al. Renal cell carcinoma with retroperitoneal lymph nodes (Impact on survival and benefits of immunotherapy). Cancer. 2003;97:2995–3002
  65. Blom JH, van Poppel H, Marechal JM, et al. Radical nephrectomy with and without lymph node dissection: Preliminary results of EORTC randomized Phase III protocol 30881. EORTC Genitourinary Group. Eur Urol. 1999;36:570–575
  66. Terrone C, Cracco C, Porpiglia F, et al. Reassessing the current TNM lymph node staging for renal cell carcinoma. Eur Urol. 2006;49:324–331

PII: S1078-1439(07)00148-2

doi: 10.1016/j.urolonc.2007.05.017

Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 3 , Pages 225-238 , May 2008

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