Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 4 , Pages 386-391 , July 2008

Phospholipase-C gamma-1 (PLCγ-1) is critical in hepatocyte growth factor induced in vitro invasion and migration without affecting the growth of prostate cancer cells

  • Gaynor Davies, Ph.D.

      Affiliations

    • Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • ,
  • Tracey A. Martin, Ph.D.

      Affiliations

    • Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44-0-29-20744711; fax: +44-0-29-20761623.
    • ,
  • Lin Ye, M.D.

      Affiliations

    • Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • ,
  • Jonathon M. Lewis-Russell, M.D.

      Affiliations

    • Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom
    • ,
  • Malcolm D. Mason, M.D.

      Affiliations

    • Department of Medicine, Section of Clinical Oncology, Velindre Hospital, Cardiff and Vale NHS Trust, Cardiff, United Kingdom
    • ,
  • Wen G. Jiang, M.D.

      Affiliations

    • Metastasis and Angiogenesis Research Group, Department of Surgery, School of Medicine, Cardiff University, Cardiff, United Kingdom

Received 22 February 2007 ,Revised 21 June 2007 ,Accepted 21 June 2007.

References 

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  3. Rana RS, Kowluru A, MacDonald MJ. Secretagogue-responsive and -unresponsive pools of phosphatidylinositol in pancreatic islets. Arch Biochem Biophys. 1986;245:411–416
  4. Liao HJ, Ji QS, Carpenter G. Phospholipase C-γ1 is required for the induction of immediate early genes by platelet-derived growth factor. J Biol Chem. 2001;23:8627–8630276
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  6. Jiang WG, Martin TA, Parr C, et al. Hepatocyte growth factor, its receptor, and their potential value in cancer therapies. Crit Rev Oncol Hematol. 2005;53:35–69
  7. Okano Y, Mizuno K, Osada S, et al. Tyrosine phosphorylation of phospholipase C-γ in C-met/HGF receptor-stimulated hepatocytes: Comparison with HepG2 hepatocarcinoma cells. Biochem Biophys Res Commun. 1993;190:842–848
  8. Wells A. Tumor invasion: Role of growth factor-induced cell motility. Adv Cancer Res. 2000;78:31–101
  9. Shepard CR, Kassis J, Whaley DL, et al. PLCγ contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene. 2007;26:3020–3026
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  11. Jiang WG, Grimshaw D, Leterra J, et al. Suppression of invasiveness and cellular motility of breast cancer cells by a hammerhead ribozyme encoding cMET antisense. Clin Cancer Res. 2001;7:2555–2562
  12. Jiang WG, Grimshaw D, Lane J, et al. Retroviral hammerhead transgene to c-MET and HGF/SF inhibited growth of breast tumor induced by fibroblasts. Clin Cancer Res. 2003;9:4274–4281
  13. Abounader R, Ranganathan S, Lal B, et al. Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression. J Natl Cancer Inst. 1999;91:1548–1556
  14. Jiang WG, Davies G, Fodstad O. Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-β connect. Biochem Biophys Res Commun. 2005;330:253-26
  15. Davies G, Watkins G, Mason MD, et al. Targeting the HGF/SF receptor c-Met using a Hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells. The prostate. 2004;60:317–324
  16. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156–159
  17. Davies G, Jiang WG, Mason MD. Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: A key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clin Cancer Res. 2001;7:3289–3297
  18. Martin TA, Parr C, Davies G, et al. Growth and angiogenesis of human breast cancer in a nude mouse tumor model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis. 2003;24:1317–1323
  19. Carraway RE, Gui X, Cochrane DE. Ca2+ channel blockers enhance neurotensin (NT) binding and inhibit NT-induced inositol phosphate formation in prostate cancer PC3 cells. J Pharmacol Exp Ther. 2003;307:640–650Erratum: J Pharmacol Exp Ther 2004;309:439
  20. Faletto DL, Kaplan DR, Halverson DO, et al. Signal transduction in c-met mediated motogenesis. EXS. 1993;65:107–130
  21. Gual P, Giordano S, Williams TA, et al. Sustained recruitment of phospholipase C-γ to Gab1 is required for HGF-induced branching tubulogenesis. Oncogene. 2000;16:1509–1518
  22. Kassis J, Moellinger J, Lo H, et al. A role for phospholipase C-γ-mediated signaling in tumor cell invasion. Clin Cancer Res. 1999;5:2251–2260
  23. Machide M, Kamitori K, Kohsaka S. Hepatocyte growth factor-induced differential activation of phospholipase Cγ-1 and phosphatidylinositol 3-kinase is regulated by tyrosine phosphatase SHP-1 in astrocytes. J Biol Chem. 2000;275:31392–31398
  24. Kochhar KS, Iyer AP. Hepatocyte growth factor induces activation of Nck and phospholipase C-γ in lung carcinoma cells. Cancer Lett. 1996;12:163–169104

PII: S1078-1439(07)00186-X

doi: 10.1016/j.urolonc.2007.06.003

Urologic Oncology: Seminars and Original Investigations
Volume 26, Issue 4 , Pages 386-391 , July 2008

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