Urologic Oncology: Seminars and Original Investigations
Volume 27, Issue 4 , Pages 373-376 , July 2009

Association of chromosomal locus 8q24 and risk of prostate cancer: A hospital-based study of German patients treated with brachytherapy

  • Andreas Meyer, M.D.

      Affiliations

    • Hannover Prostate Cancer Study Group, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    • ,
  • Peter Schürmann

      Affiliations

    • Department of Gynecology, Hannover Medical School, Hannover, Germany
    • ,
  • Maryam Ghahremani

      Affiliations

    • Department of Gynecology, Hannover Medical School, Hannover, Germany
    • ,
  • Ertan Kocak

      Affiliations

    • Department of Gynecology, Hannover Medical School, Hannover, Germany
    • ,
  • Maria-Jantje Brinkhaus

      Affiliations

    • Department of Gynecology, Hannover Medical School, Hannover, Germany
    • Department of Pediatrics, Hannover Medical School, Hannover, Germany
    • ,
  • Michael Bremer, M.D.

      Affiliations

    • Hannover Prostate Cancer Study Group, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    • ,
  • Johann H. Karstens, M.D.

      Affiliations

    • Hannover Prostate Cancer Study Group, Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    • ,
  • Jörn Hagemann, M.D.

      Affiliations

    • Department of Urology, Hannover Medical School, Hannover, Germany
    • ,
  • Stefan Machtens, M.D.

      Affiliations

    • Department of Urology, Hannover Medical School, Hannover, Germany
    • Present address: Clinics of Urology, Marien-Hospital, Bergisch Gladbach, Germany.
    • ,
  • Thilo Dörk, Ph.D.

      Affiliations

    • Department of Gynecology, Hannover Medical School, Hannover, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-511-532-6075; fax: +49-511-532-6081

Received 23 January 2008 ,Revised 7 April 2008 ,Accepted 8 April 2008.

References 

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  2. Gonzalgo ML, Isaacs WB. Molecular pathways to prostate cancer. J Urol. 2003;170:2444–2452
  3. Johns LE, Houlston RS. A systematic review and meta-analysis of familial prostate cancer risk. BJU Int. 2003;91:789–794
  4. Schaid DJ. The complex genetic epidemiology of prostate cancer. Hum Mol Genet. 2004;13:R103–R121
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  10. Yeager M, Orr N, Hayes RB, et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet. 2007;39:645–649
  11. Schumacher FR, Feigelson HS, Cox DG, et al. A common 8q24 variant in prostate and breast cancer from a large nested case-control study. Cancer Res. 2007;67:2951–2956
  12. Severi G, Hayes VM, Padilla EJ, et al. The common variant rs1447295 on chromosome 8q24 and prostate cancer risk: results from an Australian population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2007;16:610–612
  13. Suuriniemi M, Agalliu I, Schaid DJ, et al. Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epidemiol Biomarkers Prev. 2007;16:809–814
  14. Wang L, McDonnell SK, Slusser JP, et al. Two common chromosome 8q24 variants are associated with increased risk for prostate cancer. Cancer Res. 2007;67:2944–2950
  15. Easton DF, Pooley KA, Dunning AM, et al. A genome-wide association study identifies novel breast cancer susceptibility loci. Nature. 2007;447:1087–1093
  16. Machtens S, Baumann R, Hagemann J, et al. Long-term results of interstitial brachytherapy (LDR-Brachytherapy) in the treatment of patients with prostate cancer. World J Urol. 2006;24:289–295
  17. Meyer A, Wilhelm B, Dörk T, et al. ATM missense variant P1054R predisposes to prostate cancer. Radiother Oncol. 2007;83:283–288
  18. Fletcher O, Johnson N, Gibson L, et al. Association of genetic variants at 8q24 with breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17:702–705
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  20. Flaig TW, Nordeen SK, Lucia MS, et al. Conference report and review: Current status of biomarkers potentially associated with prostate cancer outcomes. J Urol. 2007;177:1229–1237

PII: S1078-1439(08)00084-7

doi: 10.1016/j.urolonc.2008.04.010

Urologic Oncology: Seminars and Original Investigations
Volume 27, Issue 4 , Pages 373-376 , July 2009

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