Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 3 , Pages 285-289 , May 2010

Retinoblastoma protein expression predicts response to bacillus Calmette-Guérin immunotherapy in patients with T1G3 bladder cancer

  • Luigi Cormio, M.D., Ph.D.

      Affiliations

    • Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39-320-8584073; fax: +39-(0)881-732111
    • ,
  • Isabella Tolve, Ph.D.

      Affiliations

    • Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
    • ,
  • Pasquale Annese, M.D.

      Affiliations

    • Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
    • ,
  • Alberto Saracino, M.D.

      Affiliations

    • Urology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    • ,
  • Rosanna Zamparese, M.D.

      Affiliations

    • Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Foggia, Italy
    • ,
  • Francesca Sanguedolce, M.D., Ph.D.

      Affiliations

    • Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Foggia, Italy
    • ,
  • Pantaleo Bufo, M.D., Ph.D.

      Affiliations

    • Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Foggia, Italy
    • ,
  • Michele Battaglia, M.D.

      Affiliations

    • Urology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    • ,
  • Francesco Paolo Selvaggi, M.D.

      Affiliations

    • Urology Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
    • ,
  • Giuseppe Carrieri, M.D.

      Affiliations

    • Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy

Received 21 June 2008 ,Revised 12 August 2008 ,Accepted 15 August 2008.

References 

  1. Lebret T, Gaudez F, Hervé , et al. Low-dose BCG instillations in the treatment of stage T1 grade 3 bladder tumors: Recurrence, progression, and success. Eur Urol. 1998;34:67–72
  2. Manoharan M, Soloway MS. Optimal management of the T1G3 bladder cancer. Urol Clin North Am. 2005;32:133–145
  3. Malkowicz SB, Nichols P, Lieskovsky G, et al. The role of radical cystectomy in the management of high grade superficial bladder cancer (PA, P1, PIS, and P2). J Urol. 1990;144:641–645
  4. Herr HW, Sogani PC. Does early cystectomy improve the survival of patients with high risk superficial bladder tumors?. J Urol. 2001;166:1296–1299
  5. Saint F, Salomon L, Quintela R, et al. Do prognostic parameters of remission versus relapse after bacillus Calmette-Guérin (BCG) immunotherapy exist? Analysis of a quarter of century literature. Eur Urol. 2003;43:351–360
  6. Logothetis CJ, Xu XJ, Ro JY, et al. Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. J Natl Cancer Inst. 1992;84:1256–1261
  7. Cordon-Cardo C, Wartinger D, Petrylak D, et al. Altered expression of the retinoblastoma gene product: Prognostic indicator in bladder cancer. J Natl Cancer Inst. 1992;84:1251–1256
  8. Cote RJ, Dunn MD, Chatterjee SJ, et al. Elevated and absent pRB expression is associated with bladder cancer progression and has cooperative effects with p53. Cancer Res. 1998;58:1090–1094
  9. Chatterjee SJ, Datar R, Youssefzadeh D, et al. Combined effects of p53, p21, and pRB expression in the progression of bladder transitional cell carcinoma. J Clin Oncol. 2004;22:1007–1013
  10. Shariat SF, Tokunaga H, Zhou J, et al. p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Oncol. 2004;22:1014–1024
  11. Cordon-Cardo C, Zhang ZF, Dalbagni G, et al. Cooperative effects of the p53 and pRB alterations in primary superficial bladder tumors. Cancer Res. 1997;57:1217–1221
  12. Grossman HB, Liebert M, Antelo M, et al. P53 and RB expression predict progression in T1 bladder cancer. Clin Cancer Res. 1998;4:829–834
  13. Hitchings AW, Kumar M, Jordan S, et al. Prediction of progression in pTa and pT1 bladder carcinomas with p53, p16, and pRB. Br J Cancer. 2004;91:552–557
  14. Wang JY. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res. 2005;15:43–48
  15. Ying L, Marino J, Hussain SP, et al. Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Res. 2005;65:9132–9136
  16. Ying L, Hofseth AB, Browning DD, et al. Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. Cancer Res. 2007;67:9286–9293

PII: S1078-1439(08)00219-6

doi: 10.1016/j.urolonc.2008.08.003

Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 3 , Pages 285-289 , May 2010

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