Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 5 , Pages 492-499 , September 2010

The International Testicular Cancer Linkage Consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred

  • Phuong L. Mai, M.D., M.S.

      Affiliations

    • Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-301-496-9928; fax: +1-301-496-1854
  • ,
  • Michael Friedlander, M.D.

      Affiliations

    • Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney, Australia
  • ,
  • Kathy Tucker, M.B.B.S.

      Affiliations

    • Department of Medical Oncology, Division of Medicine, University of New South Wales and Prince of Wales Hospital Randwick, Sydney, Australia
  • ,
  • Kelly-Anne Phillips, M.D., M.B.B.S.

      Affiliations

    • Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, East Melbourne, Australia
  • ,
  • David Hogg, M.D.

      Affiliations

    • Princess Margaret Hospital and University of Toronto, Toronto, Canada
  • ,
  • Michael A.S. Jewett, M.D.

      Affiliations

    • Princess Margaret Hospital and University of Toronto, Toronto, Canada
  • ,
  • Radka Lohynska, M.D.

      Affiliations

    • University Hospital, Department of Radiotherapy and Oncology, Prague, Czech Republic
  • ,
  • Gedske Daugaard, M.D., D.M.Sc.

      Affiliations

    • Department of Oncology, Rigshospitalet, Copenhagen, Denmark
  • ,
  • Stéphane Richard, M.D., Ph.D.

      Affiliations

    • Génétique Oncologique EPHE-CNRS FRE 2939 Faculté de Médecine Paris-Sud; Service d'Urologie, CHU, Le Kremlin-Bicêtre; Institut Gustave Roussy, Villejuif, France
  • ,
  • Catherine Bonaïti-Pellié, M.D., Ph.D.

      Affiliations

    • INSERM U 535, Villejuif, F-94817 France; Univ Paris-Sud, Villejuif, France
  • ,
  • Axel Heidenreich, M.D.

      Affiliations

    • Department of Urology, Division of Oncological Urology, University of Köln, Köln, Germany
  • ,
  • Peter Albers, M.D.

      Affiliations

    • Department of Urology, Klinikum Kassel GmbH, Kassel, Germany
  • ,
  • Istvan Bodrogi, M.D.

      Affiliations

    • Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary
  • ,
  • Lajos Geczi, M.D.

      Affiliations

    • Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary
  • ,
  • Edith Olah, Ph.D., D.Sc.

      Affiliations

    • Department of Molecular Genetics and Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary
  • ,
  • Peter A. Daly, M.D.

      Affiliations

    • Department of Medical Oncology, St James's Hospital, Dublin, Ireland
  • ,
  • Parry Guilford, Ph.D.

      Affiliations

    • Cancer Genetics Laboratory, University of Otago, Dunedin, New Zealand
  • ,
  • Sophie D. Fosså, M.D., Ph.D.

      Affiliations

    • Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway
  • ,
  • Ketil Heimdal, M.D., Ph.D.

      Affiliations

    • Departments of Clinical Cancer Research and Medical Genetics, Rikshospitalet-Radiumhospitalet, Oslo, Norway
  • ,
  • Ludmila Liubchenko, M.D.

      Affiliations

    • Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Moscow, Russian Federation
  • ,
  • Sergei A. Tjulandin, M.D.

      Affiliations

    • Laboratory of Clinical Genetics, Institute of Clinical Oncology, N.N. Blokhin Russian Cancer Research Center, Moscow, Moscow, Russian Federation
  • ,
  • Hans Stoll, R.N., M.Sc.

      Affiliations

    • Medical Oncology, University Hospital, Basel, Switzerland
  • ,
  • Walter Weber, M.D.

      Affiliations

    • Medical Oncology, University Hospital, Basel, Switzerland
  • ,
  • Douglas F. Easton, Ph.D.

      Affiliations

    • CRC Genetic Epidemiology Unit, Cambridge, United Kingdom
  • ,
  • Darshna Dudakia

      Affiliations

    • Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
  • ,
  • Robert Huddart, M.D.

      Affiliations

    • Academic Radiotherapy Unit, Institute of Cancer Research, Sutton, Surrey, United Kingdom
  • ,
  • Michael R. Stratton, M.D., Ph.D.

      Affiliations

    • Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
  • ,
  • Lawrence Einhorn, M.D.

      Affiliations

    • Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46204, USA
  • ,
  • Larissa Korde, M.D., Ph.D

      Affiliations

    • Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
  • ,
  • Katherine L. Nathanson, M.D.

      Affiliations

    • Division of Medical Genetics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
  • ,
  • D. Timothy Bishop, Ph.D.

      Affiliations

    • Imperial Cancer Research Fund Genetic Epidemiology Lab, Ashley Wing, Leeds, United Kingdom
  • ,
  • Elizabeth A. Rapley, Ph.D.

      Affiliations

    • Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
  • ,
  • Mark H. Greene, M.D.

      Affiliations

    • Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA

Received 12 August 2008 ,Accepted 1 October 2008.

References 

  1. Ferlay J, Bray F, Pisani P, et al. GLOBOCAN 2002: Cancer Incidence, Mortality, and Prevalence Worldwide. Lyon: IARC Press; 2004;
  2. Hemminki K, Li X. Familial risk in testicular cancer as a clue to a heritable and environmental etiology. Br J Cancer. 2004;90:1765–1770
  3. Dieckmann K-P, Pichlmeier U. The prevalence of familial testicular cancer. Cancer. 1997;80:1954–1960
  4. Holzik MFL, Rapley EA, Hoekstra HJ, et al. Genetic predisposition to testicular germ-cell tumors. Lancet Oncol. 2004;5:363–371
  5. Hemminki K, Chen B. Familial risks in testicular cancer as etiological clues. Int J Androl. 2006;29:205–210
  6. Dong C, Hemminki K. Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families. Int J Cancer. 2001;92:144–150
  7. Richiardi L, Pettersson A, Akre O. Genetic and environmental risk factors for testicular cancer. Int J Androl. 2007;30:230–241
  8. Nicholson PW, Harland SJ. Inheritance and testicular cancer. Br J Cancer. 1995;71:421–426
  9. Heimdal K, Olsson H, Tretli S, et al. A segregation analysis of testicular cancer based on Norwegian and Swedish families. Br J Cancer. 1997;75:1084–1087
  10. Harland SJ, Daugaard G, Horwich A, et al. The familial influence on bilateral testicular germ cell cancer (Proceedings of the Medical Research Council Study TER2 Annual Meeting). J Clin Oncol. 2006;24:4590;[Abstract].
  11. Crockford GP, Linger R, Hockley S, et al. Genome-wide linkage screen for testicular germ cell tumor susceptibility loci. Hum Mol Genet. 2006;15:443–451
  12. Rapley EA, Crockford GP, Easton DF, et al. Localization of susceptibility genes for familial testicular germ cell tumor. APMIS. 2003;111:128–135
  13. Dieckmann KP, Pichlmeier U. Clinical epidemiology of testicular germ cell tumors. World J Urol. 2004;22:2–14
  14. Garner MJ, Turner MC, Ghadirian P, et al. Epidemiology of testicular cancer: An overview. Int J Cancer. 2005;116:331–339
  15. Fossa SD, Chen J, Schonfeld SJ, et al. Risk of contralateral testicular cancer: A population-based study of 29,515 U.S. men. J Natl Cancer Inst. 2005;97:1056–1066
  16. Sokoloff MH, Joyce GF, Wise M. Testis cancer. J Urol. 2007;177:2030–2041
  17. Agnarsson BA, Gudbjartsson T, Einarsson GV, et al. Testicular germ cell tumors in Iceland (A nationwide clinicopathological study). APMIS. 2006;114:779–783
  18. Dong C, Lonnstedt I, Hemminki K. Familial testicular cancer and second primary cancers in testicular cancer patients by histological type. Eur J Cancer. 2001;37:1878–1885
  19. Fuller DB, Plenk HP. Malignant testicular germ cell tumors in a father and two sons (Case report and literature review). Cancer. 1986;58:955–958
  20. Mills PK, Newell GR, Johnson DE. Familial patterns of testicular cancer. Urology. 1984;24:1–7
  21. Patel SR, Kvols LK, Richardson RL. Familial testicular cancer: Report of six cases and review of the literature. Mayo Clin Proc. 1990;65:804–808
  22. Sonneveld DJA, Sleijfer DT, Schraffordt Koops H, et al. Familial testicular cancer in a single-centre population. Eur J Cancer. 1999;35:1368–1373
  23. The International Testicular Cancer Linkage Consortium. Candidate regions for testicular cancer susceptibility genes. APMIS. 1998;106:64–72
  24. Dieckmann K-P, Boeckmann W, Brosig W, et al. Bilateral testicular germ cell tumors (Report of nine cases and review of the literature). Cancer. 1986;57:1254–1258
  25. Hentrich M, Weber N, Bergsdorf T, et al. Management and outcome of bilateral testicular germ cell tumors: Twenty-five-year experience in Munich. Acta Oncol. 2005;44:529–536
  26. Holzbeierlein JM, Sogani PC, Sheinfeld J. Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: The Memorial Sloan Kettering Cancer Center experience 1950 to 2001. J Urol. 2003;169:2122–2125
  27. Theodore C, Terrier-Lacombe MJ, Laplanche A, et al. Bilateral germ-cell tumors: Twenty-two-year experience at the Institut Gustave Roussy. Br J Cancer. 2004;90:55–59
  28. Pettersson A, Richiardi L, Nordenskjold A, et al. Age at surgery for undescended testis and risk of testicular cancer. N Engl J Med. 2007;356:1835–1841
  29. Oosterhuis JW, Looijenga LHJ. Current views on the pathogenesis of testicular germ cell tumors and perspectives for future research: Highlights of the 5th Copenhagen Workshop on carcinoma in situ and cancer of the testis. APMIS. 2003;111:280–289
  30. Rajpert-De Meyts E. Developmental model for the pathogenesis of testicular carcinoma in situ: Genetic and environmental aspects. Hum Reprod Update. 2006;12:303–323
  31. Aschim EL, Haugen TB, Tretli S, et al. Risk factors for testicular cancer—differences between pure nonseminoma and mixed seminoma/nonseminoma?. Int J Androl. 2006;29:458–467
  32. Giwercman A, Lundin KB, Eberhard J, et al. Linkage between androgen receptor gene CAG trinucleotide repeat length and testicular germ cell cancer histological type and clinical stage. Eur J Cancer. 2004;40:2152–2158
  33. Han S, Peschel RE. Father-son testicular tumors (Evidence for genetic anticipation? A case report and review of the literature). Cancer. 2000;88:2319–2325
  34. Fraser FC. Trinucleotide repeats not the only cause of anticipation. Lancet. 1997;350:459–460

 This research was funded in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, and supported by contracts N02-CP-11019 and N02-CP-65504 with Westat, Inc. Other funding includes grant R01 CA114478 (K.L.N.).

PII: S1078-1439(08)00266-4

doi: 10.1016/j.urolonc.2008.10.004

Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 5 , Pages 492-499 , September 2010