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Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 2
, Pages 134-138
, March 2010
Mammalian target of rapamycin: A new target in prostate cancer
References
- Sunitinib vs. interferon-α in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115–124
- Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125–134
- . Regulation of translation initiation by FRAP/mTOR. Genes Dev. 2001;15:807–826
- A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 1994;369:756–758
- . Immunopharmacology of rapamycin. Annu Rev Immunol. 1996;14:483–510
- Tuberous sclerosis complex-1 and −2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA. 2002;99:13571–13576
- TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol. 2002;4:648–657
- . Identification of TOR signaling complexes: More TORC for the cell growth engine. Cell. 2002;111:9–12
- High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res. 2004;10:6572–6578
- Phosphorylation of Akt (Ser473) is an excellent predictor of poor clinical outcome in prostate cancer. Cancer Res. 2004;64:5232–5236
- . The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004;22:2954–2963
- . The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta. 2000;1470:M21–M35
- Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004;14:1296–1302
- Phosphorylation and regulation of Akt/PKB by the rictor–mTOR complex. Science. 2005;307:1098–1101
- Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992;359:843–845
- . Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell. 2002;13:1792–1801
- . Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem. 2007;282:20534–20543
- Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes. J Biol Chem. 1993;268:3734–3738
- . Targeting the mammalian target of rapamycin (mTOR): A new approach to treating cancer. Br J Cancer. 2004;91:1420–1424
- TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell. 1996;7:25–42
- Current strategies in the management of hormone refractory prostate cancer. Cancer Treat Rev. 2003;29:171–187
- . Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. Mol Cell Biol. 1998;18:6711–6718
- Expression of mTOR signaling pathway markers in prostate cancer progression. Prostate. 2006;66:1203–1212
- . Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation. Proc Natl Acad Sci USA. 2000;97:14340–14345
- NCCN Task Force Report: mTOR inhibition in solid tumors. J Natl Comprehensive Cancer Network. 2008;6(Suppl 5):S1–S20
- . Effects of the mammalian target of rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts. Cancer Res. 2005;65:2825–2831
- Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. Oncogene. 2008;27:7106–7117
- Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer. Proc Natl Acad Sci USA. 2006;103:14477–14482
- Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem Biophys Res Commun. 2003;310:1124–1132
- . Functions and regulation of transforming growth factor-beta (TGF-β) in the prostate. Eur J Cancer. 2005;41:846–857
- Signaling of transforming growth factor-β family members through SMAD proteins. Eur J Biochem. 2000;267:6954–6967
- . Role of transforming growth factor-β in human disease. N Engl J Med. 2000;342:1350–1358
- . Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis. Crit Rev Oncog. 1993;4:493–540
- . Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev. 1996;7:93–102
- Rapamycin induces Smad activity in prostate cancer cell lines. Urol Res. 2003;30:380–386
- . Mammalian target of rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer cells. J Urol. 2004;172(4 Pt 1):1333–1337
- Temsirolimus, interferon α, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271–2281
- Phase I/II trial of temsirolimus combined with interferon α for advanced renal cell carcinoma. J Clin Oncol. 2007;25:3958–3964
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol. 2004;22:909–918
PII: S1078-1439(09)00097-0
doi: 10.1016/j.urolonc.2009.03.023
© 2010 Elsevier Inc. All rights reserved.
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Urologic Oncology: Seminars and Original Investigations
Volume 28, Issue 2
, Pages 134-138
, March 2010
