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Urologic Oncology: Seminars and Original Investigations
Article in Press
mTOR pathway inhibition in renal cell carcinoma
References
- Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
- Sunitinib vs. interferon α in metastatic renal-cell carcinoma. NEJM. 2007;356:115–124
- Sorafenib in advanced clear-cell renal-cell carcinoma. NEJM. 2007;356:125–134
- Bevacizumab plus interferon α-2a for treatment of metastatic renal-cell carcinoma: A randomised, double-blind phase III trial. Lancet. 2007;370:2103–2111
- Temsirolimus, interferon α, or both, for advanced renal-cell carcinoma. NEJM. 2007;356:2271–2281
- Efficacy of everolimus in advanced renal-cell carcinoma: A randomized, double-blind, placebo-controlled phase III trial. Lancet. 2008;372:449–456
- . Mechanisms of disease: Survival benefit of temsirolimus validates a role for mTOR in the management of advanced RCC. Nat Clin Pract Oncol. 2008;5:601–609
- . Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005;37:19–24
- . Ras, PI(3)K, and mTOR signaling controls tumor cell growth. Nature. 2006;441:424–430
- . Therapeutic targets: mTOR and related pathways. Cancer Biol Ther. 2006;5:1065–1073
- . Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9–22
- . Inhibition of mTOR in kidney cancer. Urol Oncol. 2009;16(S1):S33–S39
- Regulation of hypoxia-inducible factor 1-α expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002;22:7004–7014
- . The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy. Clin Cancer Res. 2007;13:3109–3114
- Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005;307:1098–1101
- . The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 2006;7:606–619
- Targeting von Hippel-Lindau pathway in renal cell carcinoma. Clin Cancer Res. 2006;12:7215–7220
- . Targeted inhibition of mammalian target of rapamycin for the treatment of advanced renal cell carcinoma. Cancer. 2009;115:3618–3630
- Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer. 2002;99:53–57
- Activation of the mTOR signaling pathway in renal clear cell carcinoma. J Urol. 2007;177:346–352
- Prognostic relevance of the mTOR pathway in renal cell carcinoma. Cancer. 2007;109:2257–2267
- . Rapamycin (AY22.989), a new antifungal antibiotic (II. Fermentation, isolation, and characterization). J Antibiot (Tokyo). 1975;28:727–732
- TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell. 1994;5:105–108
- A mammalian protein target by G1-arresting rapamycin-receptor complex. Nature. 1994;369:756–758
- Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995;270:815–822
- Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. Clin Cancer Res. 2001;7:1758–1764
- mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer. 2001;8:249–258
- Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol. 2004;22:1–2
- A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer. Clin Cancer Res. 2006;12:5755–5763
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory cell carcinoma. J Clin Oncol. 2004;22:909–918
- Interferon-α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol. 2002;20:289–296
- Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol. 2008;26:1588–1595
- Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol. 2008;26:1603–1610
- A phase II trial of RAD001 in patients with metastatic renal cell carcinoma. J Clin Oncol. 2007;25(18 suppl):261s
- A phase II trial of RAD001 in patients with metastatic renal cell carcinoma. Cancer. 2009;115:2438–2446
- Merchan JR, Pitot HC, Qin R, et al. Phase I/II trial of CCI-779 and bevacizumab in advanced renal cell carcinoma (RCC): Safety and activity in RTKI refractory patients. J Clin Oncol 20;27(Suppl):15s [Abstract 5039].
- A phase I, pharmacokinetic and pharmacodynamic study of sorafenib, a multitargeted kinase inhibitor in combination with temsirolimus, an mTOR inhibitor, in patients with advanced solid malignancies. Proc Am Soc Clin Oncol. 2007;25(Suppl):141s;[Abstract 3512].
- Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. Clin Genitourin Cancer. 2009;7:24–27
- Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. PNAS. 2001;98:10314–10319
- . Resistance to targeted therapy in renal cell carcinoma. Lancet Oncol. 2009;10:992–1000
PII: S1078-1439(09)00361-5
doi: 10.1016/j.urolonc.2009.11.008
© 2010 Elsevier Inc. All rights reserved.
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Urologic Oncology: Seminars and Original Investigations
Article in Press
