Subepithelial growth patterns in urothelial carcinoma—frequency and prognostic significance

(A) A low grade papillary tumor with endophytic component. Part of the tumor is growing below a normal looking urothelium (arrow) H and E ×50. (B) A high grade tumor with endophytic component. Tis is seen on surface epithelium, H and E ×100. (C) Tis of the surface epithelium and involving a von Brunn's nest, H and E ×100. (Color version of figure is available online.)

Kaplan Meier curves for tumor recurrence, progression, and disease specific survival (A–C) for patients with endophytic growth pattern and D–F for patients with von Brunn's nests involvement. The numbers above and below the curves represent the number of “patients at risk” without and with the feature. (Color version of figure is available online.)