Urologic Oncology: Seminars and Original Investigations
Volume 30, Issue 2 , Pages 182-187 , March 2012

Impact of the expression of Aurora-A, p53, and MIB-1 on the prognosis of urothelial carcinomas of the upper urinary tract

  • Sylvia Scarpini, M.D.

      Affiliations

    • Academic Pathology Department, Hôpital La Pitié Salpêtrière, Université Pierre et Marie Curie, Paris, France
  • ,
  • Morgan Rouprêt, M.D., Ph.D.

      Affiliations

    • Academic Urology Department, Hôpital La Pitié Salpêtrière, Université Pierre et Marie Curie, Paris, France
    • CeRePP, Centre d'Etudes et de Recherche sur les Pathologies Prostatiques, University Paris, Paris, France
    • Corresponding Author InformationCorresponding author. Tel.: +003-3660544166; fax: +003-142177112
  • ,
  • Raphaële Renard-Penna, M.D.

      Affiliations

    • Academic Radiology Department, Hôpital La Pitié Salpêtrière, Université Pierre et Marie Curie, Paris, France
  • ,
  • Philippe Camparo, M.D.

      Affiliations

    • Pathology Department, Hôpital d'Instructions des Armées Val-de-Grâce, Paris, France
  • ,
  • Olivier Cussenot, M.D., Ph.D.

      Affiliations

    • Academic Urology Department, Hôpital Tenon, Université Pierre et Marie Curie, Paris, France
    • CeRePP, Centre d'Etudes et de Recherche sur les Pathologies Prostatiques, University Paris, Paris, France
  • ,
  • Eva Compérat, M.D., Ph.D.

      Affiliations

    • Academic Pathology Department, Hôpital La Pitié Salpêtrière, Université Pierre et Marie Curie, Paris, France

Received 21 October 2009 ,Revised 29 November 2009 ,Accepted 1 December 2009.

References 

  1. Comperat E , Bieche I , Dargere D , et al.  Gene expression study of Aurora-A reveals implication during bladder carcinogenesis and increasing values in invasive urothelial cancer . Urology . 2008;72:873–877
  2. Comperat E , Camparo P , Haus R , et al.  Aurora-A/STK-15 is a predictive factor for recurrent behavior in noninvasive bladder carcinoma: A study of 128 cases of noninvasive neoplasms . Virchows Arch . 2007;450:419–424
  3. Frank I , Cheville JC , Blute ML , et al.  Prognostic value of p53 and MIB-1 in transitional cell carcinoma of the urinary bladder with regional lymph node involvement . Cancer . 2004;101:1803–1808
  4. Catto JW , Azzouzi AR , Amira N , et al.  Distinct patterns of microsatellite instability are seen in tumors of the urinary tract . Oncogene . 2003;22:8699–8706
  5. Roupret M , Catto J , Coulet F , et al.  Microsatellite instability as indicator of MSH2 gene mutation in patients with upper urinary tract transitional cell carcinoma . J Med Genet . 2004;41:e91
  6. Vogelstein B , Kinzler KW . p53 Function and dysfunction . Cell . 1992;70:523–526
  7. Bartek J , Bartkova J , Vojtesek B , et al.  Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies . Oncogene . 1991;6:1699–1703
  8. Brown DC , Gatter KC . Ki67 protein: The immaculate deception? . Histopathology . 2002;40:2–11
  9. Kamijima S , Tobe T , Suyama T , et al.  The prognostic value of p53, Ki-67 and matrix metalloproteinases MMP-2 and MMP-9 in transitional cell carcinoma of the renal pelvis and ureter . Int J Urol . 2005;12:941–947
  10. Fromont G , Roupret M , Amira N , et al.  Tissue microarray analysis of the prognostic value of E-cadherin, Ki67, p53, p27, survivin, and MSH2 expression in upper urinary tract transitional cell carcinoma . Eur Urol . 2005;48:764–770
  11. Habuchi T , Marberger M , Droller MJ , et al.  Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers . Urology . 2005;66:64–74
  12. Bischoff JR , Plowman GD . The Aurora/Ipl1p kinase family: Regulators of chromosome segregation and cytokinesis . Trends Cell Biol . 1999;9:454–459
  13. Ducat D , Zheng Y . Aurora kinases in spindle assembly and chromosome segregation . Exp Cell Res . 2004;301:60–67
  14. Kawamura K , Moriyama M , Shiba N , et al.  Centrosome hyperamplification and chromosomal instability in bladder cancer . Eur Urol . 2003;43:505–515
  15. Fraizer GC , Diaz MF , Lee IL , et al.  Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells . Int J Oncol . 2004;25:1631–1639
  16. Sen S , Zhou H , Zhang RD , et al.  Amplification/overexpression of a mitotic kinase gene in human bladder cancer . J Natl Cancer Inst . 2002;94:1320–1329
  17. Mhawech-Fauceglia P , Fischer G , Beck A , et al.  Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma: A retrospective TMA study of 246 patients with long-term follow-up . Eur J Surg Oncol . 2006;32:439–444
  18. Gerdes J , Becker MH , Key G , et al.  Immunohistologic detection of tumor growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues . J Pathol . 1992;168:85–86
  19. Vojtesek B , Bartek J , Midgley CA , et al.  An immunochemical analysis of the human nuclear phosphoprotein p53 (New monoclonal antibodies and epitope mapping using recombinant p53) . J Immunol Methods . 1992;151:237–244
  20. Hall MC , Womack S , Sagalowsky AI , et al.  Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: A 30-year experience in 252 patients . Urology . 1998;52:594–601
  21. Jemal A , Siegel R , Ward E , et al.  Cancer statistics, 2009 . CA Cancer J Clin . 2009;59:225–249
  22. McCredie M , Stewart JH , Ford JM . Analgesics and tobacco as risk factors for cancer of the ureter and renal pelvis . J Urol . 1983;130:28–30
  23. Lin YG , Immaneni A , Merritt WM , et al.  Targeting aurora kinase with MK-0457 inhibits ovarian cancer growth . Clin Cancer Res . 2008;14:5437–5446
  24. Munoz JJ , Ellison LM . Upper tract urothelial neoplasms: Incidence and survival during the last 2 decades . J Urol . 2000;164:1523–1525
  25. Park S , Hong B , Kim CS , et al.  The impact of tumor location on prognosis of transitional cell carcinoma of the upper urinary tract . J Urol . 2004;171:621–625
  26. Catto JW , Yates DR , Rehman I , et al.  Behavior of urothelial carcinoma with respect to anatomical location . J Urol . 2007;177:1715–1720
  27. Lehmann J , Suttmann H , Kovac I , et al.  Transitional cell carcinoma of the ureter: Prognostic factors influencing progression and survival . Eur Urol . 2007;51:1281–1288
  28. Zigeuner R , Tsybrovskyy O , Ratschek M , et al.  Prognostic impact of p63 and p53 expression in upper urinary tract transitional cell carcinoma . Urology . 2004;63:1079–1083
  29. Kamai T , Takagi K , Asami H , et al.  Prognostic significance of p27Kip1 and Ki-67 expression in carcinoma of the renal pelvis and ureter . BJU Int . 2000;86:14–19
  30. Hong B , Park S , Hong JH , et al.  Prognostic value of lymphovascular invasion in transitional cell carcinoma of upper urinary tract . Urology . 2005;65:692–696
  31. Saito K , Kawakami S , Fujii Y , et al.  Lymphovascular invasion is independently associated with poor prognosis in patients with localized upper urinary tract urothelial carcinoma treated surgically . J Urol . 2007;178:2291–2296

PII: S1078-1439(09)00403-7

doi: 10.1016/j.urolonc.2009.12.003

Urologic Oncology: Seminars and Original Investigations
Volume 30, Issue 2 , Pages 182-187 , March 2012