Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection

Lin, Hui-Hui; Ke, Hung-Lung; Wu, Wen-Jeng; Lee, Ying-Huei; Chang, Lin-Li

doi:10.1016/j.urolonc.2010.01.002

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Hypermethylation of E-cadherin, p16, p14, and RASSF1A genes in pathologically normal urothelium predict bladder recurrence of bladder cancer after transurethral resection

Hui-Hui Lin, B.S.
- Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Hung-Lung Ke, M.D., M.S.
- Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Wen-Jeng Wu, M.D., Ph.D.
- Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
- Department of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Ying-Huei Lee, M.D., Ph.D.
- Department of Urology, Chi Mei Medical Center, Tainan, Taiwan
- These authors contributed equally to this work.
Lin-Li Chang, Ph.D.
- Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
- Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
- Corresponding author. Tel.: +886-7-3121101, ext: 2150; fax: +886-7-3211033.
- These authors contributed equally to this work.

Received 8 October 2009; received in revised form 8 January 2010; accepted 9 January 2010. published online 27 August 2010.
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☆This study was sponsored by the Department of Urology, Chi Mei Medical Center, Tainan, Taiwan, and the Department of Urology, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan (95CM-KMU-08).