Urologic Oncology: Seminars and Original Investigations
Volume 30, Issue 3 , Pages 319-324 , May 2012

The incidence and management of metachronous testicular germ cell tumors in patients with extragonadal germ cell tumors

  • Kenji Hashimoto, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Hiroyuki Fujimoto, M.D.

      Affiliations

    • Urology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Tsutomu Kouno, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81-3-3542-2511; fax: +81-3-3542-3815
    • ,
  • Masahiro Koseki, M.D., M.Sc.

      Affiliations

    • Division of Biostatistics, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    • ,
  • Kan Yonemori, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Taizo Hirata, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Mayu Yunokawa, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Chikako Shimizu, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Noriyuki Katsumata, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Kenji Tamura, M.D., Ph.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Masashi Ando, M.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Masahiro Takeuchi, M.D., M.P.H.

      Affiliations

    • Division of Biostatistics, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
    • ,
  • Hiroyuki Nakanishi, M.D.

      Affiliations

    • Urology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Motokiyo Komiyama, M.D.

      Affiliations

    • Urology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Tohru Nakagawa, M.D., Ph.D.

      Affiliations

    • Urology Division, National Cancer Center Hospital, Tokyo, Japan
    • ,
  • Yasuhiro Fujiwara, M.D., Ph.D.

      Affiliations

    • Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan

Received 14 January 2010 ,Revised 10 February 2010 ,Accepted 10 February 2010.

References 

  1. Bosl GJ , Motzer RJ . Testicular germ-cell cancer . N Engl J Med . 1997;337:242–253
  2. Dueland S , Stenwig AE , Heilo A , et al.  Treatment and outcome of patients with extragonadal germ cell tumours—the Norwegian Radium Hospital's experience 1979–94 . Br J Cancer . 1998;77:329–335
  3. Scholz M , Zehender M , Thalmann GN , et al.  Extragonadal retroperitoneal germ cell tumor: Evidence of origin in the testis . Ann Oncol . 2002;13:121–124
  4. Fossa SD , Aass N , Heilo A , et al.  Testicular carcinoma in situ in patients with extragonadal germ-cell tumours: The clinical role of pretreatment biopsy . Ann Oncol . 2003;14:1412–1418
  5. Daugaard G , Rorth M , von der Maase H , et al.  Management of extragonadal germ-cell tumors and the significance of bilateral testicular biopsies . Ann Oncol . 1992;3:283–289
  6. Christensen TB , Daugaard G , Geertsen PF , et al.  Effect of chemotherapy on carcinoma in situ of the testis . Ann Oncol . 1998;9:657–660
  7. Hartmann JT , Fossa SD , Nichols CR , et al.  Incidence of metachronous testicular cancer in patients with extragonadal germ cell tumors . J Natl Cancer Inst . 2001;93:1733–1738
  8. McAleer JJ , Nicholls J , Horwich A . Does extragonadal presentation impart a worse prognosis to abdominal germ-cell tumours? . Eur J Cancer . 1992;28A:825–828
  9. Gerl A , Clemm C , Lamerz R , et al.  Cisplatin-based chemotherapy of primary extragonadal germ cell tumors (A single institution experience) . Cancer . 1996;77:526–532
  10. Lokich J . Metachronous gonadal and extragonadal primary germ cell tumors: Two case reports . Cancer Invest . 1994;12:406–408
  11. Allaway M , Nseyo UO . Primary testicular seminoma in a patient with a history of extragonadal non-seminomatous germ cell carcinoma . Urology . 2000;55:949–950
  12. Hayashi T , Mine M , Kojima S , et al.  Extragonadal germ cell tumor followed by metachronous testicular tumor (A case report) . Urol Int . 1996;57:194–196
  13. Gonzalez-Quintela A , Lopez-Bonet E , Roman J , et al.  Testicular germ cell tumor 7 years after a retroperitoneal germ cell tumor . Eur Urol . 1991;19:336–338
  14. Daniel C , Fizazi K , Culine S , et al.  Metachronous gonadal and extragonadal primaries, or late relapse of germ cell tumor? . Urol Oncol . 2001;6:49–52
  15. Kuroda I , Ueno M , Mitsuhashi T , et al.  Testicular seminoma after the complete remission of extragonadal yolk sac tumor: A case report . BMC Urol . 2004;4:13
  16. Oosterhuis JW , Stoop H , Honecker F , et al.  Why human extragonadal germ cell tumours occur in the midline of the body: Old concepts, new perspectives . Int J Androl . 2007;30:256–263 Discussion 63–4
  17. Burt ME , Javadpour N . Germ-cell tumors in patients with apparently normal testes . Cancer . 1981;47:1911–1915
  18. Motoyama T , Watanabe H , Yamamoto T , et al.  Production of β-human chorionic gonadotropin by germ cell tumors in vivo and in vitro . Acta Pathol Jpn . 1988;38:577–590
  19. van As NJ , Gilbert DC , Money-Kyrle J , et al.  Evidence-based pragmatic guidelines for the follow-up of testicular cancer: Optimizing the detection of relapse . Br J Cancer . 2008 Jun 17;98:1894–1902
  20. Bohle A , Studer UE , Sonntag RW , et al.  Primary or secondary extragonadal germ cell tumors? . J Urol . 1986;135:939–943

PII: S1078-1439(10)00049-9

doi: 10.1016/j.urolonc.2010.02.008

Urologic Oncology: Seminars and Original Investigations
Volume 30, Issue 3 , Pages 319-324 , May 2012

Article Tools

* Image Usage & Resolution