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The role of survivin and Bcl-2 in zinc-induced apoptosis in prostate cancer cells

  • Ja Hyeon Ku, M.D., Ph.D.

      Affiliations

    • Department of Urology, Seoul National University Hospital, Seoul, Korea
    • ,
  • Soo Yeon Seo, B.Sc.

      Affiliations

    • Department of Urology and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    • ,
  • Cheol Kwak, M.D., Ph.D.

      Affiliations

    • Department of Urology, Seoul National University Hospital, Seoul, Korea
    • ,
  • Hyeon Hoe Kim, M.D., Ph.D.

      Affiliations

    • Department of Urology, Seoul National University Hospital, Seoul, Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82-2-2072-2425; fax: +82-2-742-4665

Received 22 April 2010 ,Revised 29 May 2010 ,Accepted 5 June 2010. Published online 07 September 2010 Corrected Proof

References 

  1. Feng P, Li TL, Guan ZX, et al. Direct effect of zinc on mitochondrial apoptogenesis in prostate cells. Prostate. 2002;52:311–318
  2. Untergasser G, Rumpold H, Plas E, et al. High levels of zinc ions induce loss of mitochondrial potential and degradation of antiapoptotic Bcl-2 protein in in vitro cultivated human prostate epithelial cells. Biochem Biophys Res Commun. 2000;279:607–614
  3. Feng P, Liang JY, Li TL, et al. Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol. 2000;4:31–36
  4. Ganzu N, Eastman A. Zinc inhibits Bax and Bak activation and cytochrome c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways. Cell Death Differ. 2003;10:652–661
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  7. Deveraux QL, Reed JC. IAP family proteins-suppressors of apoptosis. Genes Dev. 1999;13:239–252
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  14. Hasumi M, Suzuki K, Matsui H, et al. Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. Cancer Lett. 2003;200:187–195
  15. Beck FW, Prasad AS, Butler CE, et al. Differential expression of hZnT-4 in human prostate tissues. Prostate. 2004;58:374–381
  16. Costello LC, Franklin RB. The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of prostate malignancy. Oncology. 2000;59:269–282
  17. Feng P, Li T, Guan Z, Franklin RB, et al. The involvement of Bax in zinc-induced mitochondrial apoptogenesis in malignant prostate cells. Mol Cancer. 2008;7:25
  18. Costello LC, Liu Y, Zou J, et al. Evidence for a zinc uptake transporter in human prostate cancer cells which is regulated by prolactin and testosterone. J Biol Chem. 1999;274:17499–17504
  19. Uzzo RG, Leavis P, Hatch W, et al. Zinc inhibits nuclear Factor-κB activation and sensitizes prostate cancer cells to cytotoxic agents. Clin Cancer Res. 2002;8:3579–3583
  20. Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep. 2006;7:988–994
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☆ This work was supported by grant no. 04-2008-077-0 from the SNUH Research Fund.

PII: S1078-1439(10)00158-4

doi: 10.1016/j.urolonc.2010.06.001

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